Abstract: The aim of the present study was to investigate the role of spiritual intelligence and religious orientation in explaining wisdom construct. Method of the present study was descriptive and correlational. Participants were 120 students of Bu-Ali Sina University, Hame-dan. The measures of Religious Orientation, Spiritual Intelligence Inventory, and three scalese of wisdom including Three-Dimensional Wisdom Scale (3D-WS), Adult Self-Transcendence Inven-tory (ASTI), and Fundamental Values Scale (FVS) were used. Multiple regression and Pear-son’s correlation methods were used to analyze the data. The results showed that in 3D-WS, the combination of components of spiritual intelli-gence and religious orientation explains 20 per-cent of wisdom’s total variance. No other signi-ficant relationships were found between other scales of wisdom and religious orientation; how-ever, they were significantly associated with spiri-tual intelligence.